Given that the paclitaxel was administered peripherally, T-cells are activated in the lymph nodes, and neuropathy develops in the limbs, we chose to study subpopulations of T-cells from the draining (popliteal and inguinal) lymph nodes that are CD4+ (Thelper) CD8+, CD25+/- and CD44+/- (activated T-cells), CCR7+ (effector T-cells) (Figures 3A–F). Here, CD4 is linked to neuropathy.