australis</i> infection differentially regulated a significant number of genes in bone marrow-derived macrophages (BMMs) in an <i>Atg5</i>-depdent fashion as determined by RNA sequencing and Ingenuity Pathway Analysis, including genes in the molecular networks of IL-1 family cytokines and PI3K-Akt-mTOR. The gene discussed is ATG5; the disease is infection.