Notable models include a BCL6 knock-in which results in a DLBCL-like phenotype (19), VavP-Bcl2 mice, mimicking the t(14; 18) chromosomal translocation, which develop follicular lymphomas, a targeted deletion of Trp53 – CD21-Tp53lox – that develops non-germinal center B-cell lymphomas, and Eμ-Tcl1 mice which develop aggressive chronic lymphocytic leukemia (20–22). Here, BCL6 is linked to follicular lymphoma.