Taken together, a dual role of hnRNP K has been observed in the formation of hematological malignancies, wherein an under-expression of the protein leads to a deficit in its role inducing the expression of tumor suppressors p53/p21, thus leading to a myeloproliferative phenotype and lymphoma in rodents (40), while on the other hand, an increment in the levels of hnRNP K has been related to higher levels of c-Myc and the formation of lymphomas (39, 55). Here, TP53 is linked to lymphoma.