These Traf2DNxBCL2-tg+/+ CLL/SLL stereotyped HCDR3 sequences are found in UM clones, in agreement with the findings in stereotyped HCDR3 sequences from human CLL (17) and from the above mentioned CLL mouse models (28, 32), that are also found in UM-CLL clones. This evidence concerns the gene TG and B-cell chronic lymphocytic leukemia.