TG and B-cell chronic lymphocytic leukemia: Our studies on the mechanisms causing CLL/SLL development in the Traf2DNxBCL2-tg+/+ mice showed that B cell-specific TRAF2DN expression caused proteasome-dependent degradation of endogenous TRAF2, thus rendering B cell-specific Traf2DN-tg mice into bona fide B cell-specific Traf2-deficient mice (24).