The comparison of the BCR HCDR3 sequences of the expanded Traf2DNxBcl2-tg+/+ CLL/SLL clones with similar sequences found in public databases showed high homology with HCDR3 recognizing autoantigens, such as phosphatidylcholine (82 and 75% homology), cardiolipin (86% homology), dsDNA (80% homology), as well as to pathogen antigens, such as hepatitis C virus E2 protein (81% homology), CMV glycoprotein B (76% homology), Bordetella (75% homology) and Vaccinia protein A3 (80% homology) (Table 3 and Supplementary Table 9). Here, TG is linked to B-cell chronic lymphocytic leukemia.