To determine whether this restricted IGHV gene subgroup usage was a distinctive characteristic of the Traf2DNxBCL2-tg+/+ CLL/SLL model or was instead a general feature that could also be found in the expanded B cell clones of other types of B cell malignancies, we analyzed the IGHV subgroup repertoire used by the mature non-Hodgkin lymphomas (NHL) developed by the TRAF3xBCL2-tg+/+ mice (34). Here, TG is linked to B-cell chronic lymphocytic leukemia.