TG and B-cell chronic lymphocytic leukemia: Furthermore, compared to other CLL mouse models, such as the Eμ-TCL-1-tg (28) and the MDR−/− and the miR-15a/16-1−/− (32) that only generate UM-CLL clones, the CLL/SLL developed by the Traf2DNxBCL2-tg+/+ mice produce both UM- and M-CLL/SLL clones, similar to human CLL, albeit a vast majority of them are UM.