It is also worth mentioning that HCDR3 expressed in CLL clones from the Eμ-TCL-1-tg (28), the MDR−/− and miR-15a/16-1−/− (32) and the IgH-TEμ (45) mice were also found in Traf2DNxBCL2-tg-/-,+/-,+/+ and in TRAF3xBCL2-tg+/+ mice, although none of these were expanded clones (Supplementary Table 8).This result is consistent with the existence of CLL-biased stereotyped BCR in healthy individuals (48, 49). The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.