The analysis of the HCDR3 AA sequence of the expanded Traf2DNxBCL2-tg+/+ CLL/SLL clones shows an average length of 11.6 ± 2.9 AAs, which is similar to the HCDR3 length in all other genotypes (-/-, 11.92 ± 2.7; +/-, 10.71 ± 2.6; -/+, 12.11 ± 3.3; +/+, 11.44 ± 2.8) and in accordance with the HCDR3 average length in mice (11.5 ± 1.9 AAs) (44). Here, TG is linked to B-cell chronic lymphocytic leukemia.