Many of these antigens were already described as being recognized by the BCR of human and mouse CLL clones, including phosphatidylcholine (28), cardiolipin (55, 56), dsDNA (55, 57) and CMV (58, 59), further supporting the role of these types of antigens in the etiology of Traf2DNxBcl2-tg+/+ CLL/SLL. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.