In contrast, there is a favored usage of the IGHJ4 gene by the Traf2DNxBCL2-tg+/+ mice (all clones, 58%; expanded CLL clones, 63%) compared to the mice with the other Traf2DNxBCL2 genotype combinations (p = 0.024; LR = 0.024) (Figure 3) and also compared to the average IGHJ4 gene usage in mice (21.5%) (35). The gene discussed is TG; the disease is B-cell chronic lymphocytic leukemia.