Importantly, an inducible systemic deletion of Bap1 in Bap1fl/flCreERT2 mice resulted in broad spectrum hematologic pathology, with an expansion of myeloid leukocytes, and a depletion of platelet and red blood cells, resembling myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) (38). Here, BAP1 is linked to chronic myelomonocytic leukemia.