ITPR3 and neoplasm: Other mechanisms linking BAP1 molecular functions and its tumor suppressor activity are also proposed, including: its roles in transcriptional regulation of pro-survival and pro-apoptosis transcriptional programs in cross-talk with PRC1 (89); its role as a positive regulator of ferroptosis via repression of SLC7A11 gene expression (98); its role in the transcriptional regulation of cellular metabolic programs (37, 99–101), and in the regulation of Ca2+ signaling and apoptosis via deubiquitination and stabilization of receptor-channel IP3R3 (42, 102).