BAP1 is an important tumor suppressor in human, with somatic or germinal BAP1 mutations being common in mesothelioma, uveal melanoma, renal cell carcinoma, and other cancers (43, 44), while mutations in BAP1 interacting Polycomb proteins ASXL1/2 are prevalent in myeloid leukemia (44, 45). This evidence concerns the gene BAP1 and renal cell carcinoma.