HMOX1 and cerebral malaria: Additionally, in vivo experiments demonstrated that the exposure of C57BL/6 mice infected with Plasmodium berghei ANKA to carbon monoxide (CO), another end-product from the HO-1 pathway, increased the survival and improved the symptoms of the experimental cerebral malaria (ECM), suggesting a protective property of this product against the ECM pathogenesis (Pamplona et al., 2007).