As the infection decreased the HO-1 expression levels in BeWo but did not interfere in its expression in HTR-8/SVneo cells, in the additional experiments, the effect of HO-1 induction was investigated on T. gondii proliferation, p38 MAPK phosphorylation, and IL-6, MIF, and TNF production during the infection with the parasite in BeWo cells. The gene discussed is MIF; the disease is infection.