The MTHFR C677T polymorphism increased risk for NTD in one study (69) (OR = 2.69) while another study reported an ethnic difference with Muslim mothers having a higher frequency of the TT genotype (8.7% vs 1.1% in Hindu mothers) which reflected in increased risk of NTD by 12.9 times compared to Hindus (35). The gene discussed is MTHFR; the disease is neural tube defect.