TFEB and cancer: Upregulation of TFEB in several cancers, such as pancreatic adenocarcinoma, melanoma, renal cell carcinoma colorectal cancer and non-small cell lung cancer (Davis et al., 2010; Liang et al., 2010; Giatromanolaki et al., 2015; Li et al., 2019), promotes cancer progression via mTORC1 hyperactivation signaling to promote cell proliferation and boost autophagy, producing an intracellular pool of nutrients, most importantly amino acids, and thus supporting cancer growth.