We previously reported that the Thai Herbal HRF extracts protected against UVA-induced MMP-1 in keratinocyte HaCaT cells (Pluemsamran et al., 2013) and melanogenesis in B16F10 melanoma cells through activating Nrf2-dependent antioxidant defenses (Onkoksoong et al., 2018). This evidence concerns the gene NFE2L2 and melanoma.