The study of (Yang et al., 2020) used the APP/PS1/tau triple transgenic(3 × Tg) mice as the rodent model of AD, and they found that the iridoid glycoside extracted from C. officinalis could ameliorate learning and memory impairment of 3 × Tg mice by down-regulating the expressions of Aβ and full-length amyloid precursor protein, as well as decreasing the hyperphosphorylation of tau protein. This evidence concerns the gene MAPT and Alzheimer disease.