Drug enhancement of the electrophilic counterattack organized by Nrf2 may be used as a strategy for chemoprophylaxis of cancer (Prestera et al., 1993; Satoh et al., 2013; Panieri et al., 2020), and has been well validated in various experimental cancer models in mice (Milkovic et al., 2017). The gene discussed is NFE2L2; the disease is cancer.