Moreover, Nrf2 has a broad protective effect on lung diseases such as asthma, neurodegenerative diseases such as Parkinson's disease, inflammatory diseases such as inflammatory bowel disease, liver damage, atherosclerosis, insulin resistance and so on (Sykiotis and Bohmann, 2010; Cuadrado et al., 2019). Here, NFE2L2 is linked to neurodegenerative disease.