Moreover, it was reported that methotrexate, a drug with anti-inflammatory properties used for the treatment of rheumatoid arthritis, induced the expression of lincRNA-p21, which in turn inhibited the activity of the pro-inflammatory transcription factor NF-kB in THP-1 monocyte cell lines and PBMCs (Pahl, 1999; Spurlock et al., 2014). This evidence concerns the gene NFKB1 and rheumatoid arthritis.