Recent studies have shown that PLIN2 (encoded by Plin2) and PLIN3 (encoded by Plin3) are involved in the formation of lipid droplets and in the pathophysiological process of NAFLD, which is characterized by excessive accumulation of lipids in hepatocytes (Carr and Ahima, 2016; Graffmann et al., 2016; Sahini and Borlak, 2016). This evidence concerns the gene PLIN2 and metabolic dysfunction-associated steatotic liver disease.