Markers associated with cardiac hypertrophy including atrial natriuretic peptide (A.N.P.)(∼4 fold) [t (6) = 4.296; p = 0.005] and beta-myosin heavy chain (β-MHC) (∼3.5 fold) [t (6) = 2.418; p = 0.052] were also evaluated following DOX treatment when compared to control mice (Figures 1D,E). This evidence concerns the gene NPPA and cardiac hypertrophy.