Another link between NCL and ALS/FTD was suggested by the co-segregation of NCL and some RNAs (e.g., C9orf72) or RNA binding proteins (including TDP-43 and FUS/TLS), in RNA foci accumulated in ALS patient tissues, resulting in the altered expression of specific RNA targets, RNA misprocessing events and disruption of nucleolar functions (Haeusler et al., 2014; Zhou et al., 2014; Butti and Patten, 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.