TARDBP and amyotrophic lateral sclerosis: Among NDs, the vast majority of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and also a subset of late-onset Alzheimer’s disease (AD) cases are characterized by the presence of neuronal cytoplasmic inclusions mainly composed of an ubiquitinated and hyper-phosphorylated form of the transactive response DNA binding 43 kDa protein (TDP-43) (Gao et al., 2018).