C9orf72 and amyotrophic lateral sclerosis: Intriguingly, the presence of structurally disordered regions is also shared by two other major ALS-related gene products [i.e., fused in sarcoma/translocated in liposarcoma (FUS/TLS) and C9orf72 dipeptide repeats (DPRs)], pinpointing structural transitions of disease-associated proteins as a major driving force toward neurodegeneration (Harrison and Shorter, 2017; Santamaria et al., 2017).