LRRK2 and Parkinson disease: LRRK2 mutations encode leucine-rich repeat kinase 2 (LRRK2), which is the commonest cause of PD and is associated with an increase in kinase activity (Wang et al., 2012) interacting with Drp1 to cause mitochondrial fragmentation (Yue et al., 2015; Bonello et al., 2019).