PRKN and Parkinson disease: Fly models of PINK1 and Parkin mutations summarize the dominant hallmarks of PD, including mitochondrial dysfunction, motor impairment, loss of dopaminergic neurons, and shortened lifespan (Yang et al., 2006), impairment of the PINK/Parkin pathway points to a possibility of an overlapping effect between PD and AD (Sliter et al., 2018; Xu et al., 2020).