In a genetically engineered NMDAR hypofunction model for schizophrenia, NMDAR hypofunction had spatial and temporal boundaries (Nakazawa et al., 2017): (1) The origin of NMDAR hypofunction was reported in cortical and hippocampal GABAergic neurons, particularly in parvalbumin-positive fast-spiking interneurons (Nakazawa and Sapkota, 2020). The gene discussed is PVALB; the disease is schizophrenia.