RCTs of a KD have demonstrated reductions in visceral adiposity and serum insulin levels without adversely affecting blood lipid levels despite elevated dietary fat intake.224,225 Notably, in xenograft models of pancreatic cancer, a KD also increased sensitivity to radiation—putatively by reducing oxidative stress; however, the diet was poorly tolerated in a pilot study of nine people.226. Here, INS is linked to pancreatic neoplasm.