This resultant hyperinsulinaemia can partially reactivate PI3K signalling, and following PI3K inhibition, can reactivate PI3K signalling in both normal and tumour tissues.44 A ketogenic diet, which is deficient in carbohydrate, prevents hyperinsulinaemia and can thereby reduce the paradoxical reactivation of PI3K by PI3K inhibitor-associated hyperglycaemia.44 This evidence concerns the gene PIK3CA and neoplasm.