TSC1 and neoplasm: While MTOR has the same steady-state level in both tumor and normal tissues, Fig. 1e, f suggests a trend of greater overexpression of upstream regulators of MTORC1 complex (in particular TSC1 and AKT2) in patients with longer PFS (ID 148 and ID 203), as compared with the patients with shorter PFS (ID 090, ID 227, ID 117, and ID 006).