The DDPP prototype presented here was derived from analysis of transcriptomic and clinical outcomes in patients with advanced cancer enrolled in the WINTHER clinical trial and treated with: everolimus (mTOR inhibitor), axitinib (VEGFR receptors inhibitor), afatinib (pan-HER inhibitor), trametinib (MEK inhibitor), FGFR inhibitors, and anti-PD-1/PDL-1 antibodies (pembrolizumab, nivolumab and atezolizumab). The gene discussed is CD274; the disease is cancer.