To identify proteins that colocalize with CEBPA and RUNX1 in enhancer-bound TF complexes and that are potential therapeutic targets in 3q-rearranged AML, we performed ChIP-SICAP, a method that allows for the isolation of protein complexes in their chromatin-bound state by using specific bait proteins [27]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.