RUNX1 and acute myeloid leukemia: In line with our observations, RUNX1, MYB, and ELK1 have previously been implicated in the regulation of EVI1 transcription in AML cells by studies of the minimal EVI1 promoter of the MECOM locus, which is the target of the hijacked G2DHE in 3q-rearranged AML [29].