As shown in Table 2, the multivariate logistic regression analysis revealed that baseline fibrosis stage (odds ratio 4.56, 95% confidence interval, 1.13–18.3; P = 0.033) and Ang2 level (odds ratio 1.004, 95% confidence interval, 1.00–1.01; P = 0.039) were significantly associated with non-regression of liver fibrosis stage based on LSM at 96 weeks after DAA initiation. This evidence concerns the gene ANGPT2 and fibrosis.