A univariate analysis revealed that baseline liver fibrosis stage (F0–2 vs. 3–4, P = 0.002), FIB-4 index (P = 0.005), angiopoietin-2 (P = 0.004), HCV-RNA (P = 0.025), and AST (P = 0.029) were significantly associated with non-regression at 96 weeks after DAA initiation. Here, ANGPT2 is linked to Hepatic fibrosis.