ETV5 and obesity due to melanocortin 4 receptor deficiency: MLN4924 also attenuates excessive ETV5 degradation (Fig. 7e), obesity, and diabetes development in ob/ob mice (Fig. 7f), improving their hyperglycemia (Fig. 7g), hyperinsulinemia (Fig. 7h), glucose tolerance, and insulin sensitivity (Fig. S5e, f).