Depleting COP1 or DET1 leads to the accumulation of ETV5 and, to a mild extent, ETV4 in MIN6 insulinoma cells (Fig. 3g), whereas co-expressing COP1 and DET1 diminishes ETV5 levels (Fig. 3h), suggesting that CRL4COP1/DET1 mediates ETV5 degradation, which is further supported by ETV5 stabilization upon MLN4924 treatment (Fig. 3i). This evidence concerns the gene DET1 and pancreatic insulinoma.