Indeed, MLN4924 attenuates HFD-induced ETV5 degradation (Fig. 7a), obesity (Fig. 7b), hyperinsulinemia (Fig. 7c), hyperglycemia (Fig. 7d), glucose intolerance (Fig. S5b), and insulin resistance (Fig. S5c). This evidence concerns the gene ETV5 and obesity due to melanocortin 4 receptor deficiency.