BCL2 and diffuse large B-cell lymphoma: Large-scale genome sequencing has further enabled the identification of several molecular subtypes of DLBCL based on genetic alterations affecting the proto-oncogenes BCL2/-6 and MYC, epigenetic modifiers and regulators in the B-cell receptor (BCR), nuclear factor-κB (NF-κB), NOTCH and p53 signalling pathways3,4.