Several DLBCL essential genes, as estimated from the previous two screens12,13, were detected early at day 7, including FOXO1, IRF4 and SF3B1, whereas some appeared later than day 14, e.g., TAF1, MLL2, RHOA and YY1 (Supplementary Table S1). The gene discussed is SF3B1; the disease is diffuse large B-cell lymphoma.