By re-evaluating the previously published CRISPR-Cas9 screens from a pan-cancer study and sets of DLBCL cell lines, we also identified a genetic essentiality of EP300 or CREBBP gene in a small subset of cancer cell lines, including a few DLBCL cell lines that are dependent on EP300 and carry CREBBP mutation, copy number loss or translocation. Here, EP300 is linked to diffuse large B-cell lymphoma.