It is well known that PI3K-Akt signaling pathway is not only closely related to the development and tumor metastasis of TNBC, but also recent studies have shown that the inhibition of PI3K-Akt signaling pathway mediated by PD-1/PD-L1 pathway could directly affect the proliferation and activation of T cells, thus inhibiting the process of anti-tumor immunity42,43. This evidence concerns the gene CD274 and neoplasm.