CYP3A4 and gout: It is also important to note that colchicine use in gout and advanced CKD can be hazardous when used in conjunction with some medications, such as statin therapies (CYP3A4 inhibitors), cyclosporin (both CYP3A4 and P-glycoprotein inhibitors), and macrolide antibiotic, such as clarithromycin (both CYP3A4 and P-glycoprotein inhibitors).