In the case of colorectal, bladder, hepatocellular and ovarian carcinoma alterations in TNKS expression are caused by deep deletion while in esophagogastric cancer TNKS gene amplification is responsible for most of the alterations in TNKS. Point mutations were responsible of TNKS2 alterations for most tumors with exception of prostate adenocarcinoma and B-cell neoplasms (Fig. 3a and c). Here, TNKS2 is linked to ovarian carcinoma.