In addition, TAK-242 could significantly inhibit the upregulation of Rael (a ligand for mouse NKG2D with a very similar structure to MICA/B) expression in DCs, the increased frequencies of NK cells, and the improved antitumour effects in HLA-A2.1+/ECM1+ mouse breast cancer cell-bearing mice treated with LA. This evidence concerns the gene KLRK1 and breast cancer.