For those 40 and 21 IR-DEGs, we first performed univariate and multivariate Cox analyses and found that 2 IR-DEGs (CCRL2 and HSPA1A) out of 40 negatively correlated IR-DEGs and 1 IR-DEG (SCG2) out of 21 positively correlated IR-DEGs were correlated with the overall survival (OS) of CRC patients (Fig. 2a–e). The gene discussed is CCRL2; the disease is colorectal carcinoma.