NLRP6 and osteoarthritis: An anti-inflammatory role of NLRP6 has been reported in rheumatoid arthritis patients in which NLRP6 was found to be downregulated in synovial tissues and fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis patients compared with osteoarthritis patients (Lin and Luo, 2017).