LC3-associated phagocytosis (LAP) is an important example, where LC3 conjugation to phagosomes, housing pathogens or apoptotic debris, modulates the immune response (Sanjuan et al., 2007), inflammation (Henault et al., 2012; Martinez et al., 2015, 2016), antigen presentation (Fletcher et al., 2018; Ma et al., 2012), vision (Kim et al., 2013), and tumor cell tolerance (Cunha et al., 2018). Here, MAP1LC3A is linked to neoplasm.