Recent studies also suggested a role for Zeb2 in liver fibrosis by showing that Zeb2 levels are increased in fibrotic livers, and the expression of Zeb2 in HSCs has been suggested to affect their activation in vitro.14,15 Furthermore, Zeb2 maintains the tissue-specific identity of Kupffer cells and its absence leads to Kupffer cell disappearance.16 Here, ZEB2 is linked to Hepatic fibrosis.