The incidence of IgE-mediated and non IgE-mediated reactions has not increased worldwide over the last 50 years, and a penicillin allergy label has significant consequences for individual and public health.(14) Longitudinal studies from a center in the United States showed the rate of positive penicillin skin tests decreased from 15%, in 1995, to 3%, in 2007, and to 0.8%, in 2013.(16,17). This evidence concerns the gene IGHE and Allergy.