Contrary to the enrichment of DDX46-bound RNAs after viral infection in previous study [14], we showed that these three transcripts bound to DDX5 at a reduced level after cells were infected with VSV, while there was an induction in m6A modification of the transcripts mediated by METTL3, which was also regulated by DDX5, indicating that DDX5 was associated with METTL3-mediated m6A modification of the transcripts and it may be a key mediator between m6A writer and the targeted transcripts. Here, DDX5 is linked to viral infectious disease.