Moreover, at 4 and 8 hpi, as shown in Fig 8B, the expression of DHX58 was decreased in DDX5+/- mice compared with that of wild-type littermates, while p65 and IKKγ were obviously increased in DDX5+/- mice compared with those of wild-type littermates, indicating that DDX5 regulated m6A methylation of transcript to activate the negative DHX58 pathway while inhibiting the positive p65 pathways after infection with VSV in innate immunity. This evidence concerns the gene IKBKG and infection.