CRP and COVID-19: In a sample of 781 COVID-19 positive hospitalized patients, we show significant sex differences in inflammatory markers and outcomes including (1) higher levels of both initial and peak inflammatory markers in men compared with women, (2) men with COVID-19 infection had nearly 2-fold increased odds of dying compared with women, and (3) the association of peak CRP with death and ICU admission is more pronounced in men compared with women.