The droplet to fibril transitions are of potential relevance, as cytoplasmic TDP-43 droplets were shown to sequestrate components of the nuclear pore [37] and co-aggregate formation between TDP-43 and nuclear pore components emerged as a hallmark of ALS/FTD [38,39], and they may well be hybrid amyloids similar to the RIPK1-RIPK3 necrosome core [29]. This evidence concerns the gene RIPK1 and amyotrophic lateral sclerosis.