Transactive response DNA-binding Protein of 43 kDa (TDP-43) is an RNA-binding protein that forms aberrant aggregates associated with disease contexts, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) [1], or the recently reported “LATE” dementia, which had been misdiagnosed as Alzheimer disease [2]. The gene discussed is TARDBP; the disease is frontotemporal dementia.