Although these constructs correspond to a limited part of the TDP-43 PrLD sequence as they exclude the 2 GAroS segments, these model fibrils already reveal the rich diversity of the TDP-43 PrLD amyloid foldome, which assembles distinct functional (e.g., in muscle regeneration) [3] and pathological (e.g., in FTD) [20,21] amyloid-like structures. This evidence concerns the gene TARDBP and frontotemporal dementia.