However, the statistical power to detect an association between T2D risk and ANGPTL8 protein-truncating variation was higher in the FinnGen data due to a considerably higher number of T2D cases (29,166) compared to both the previous study by Clapham et al. [30] (14,824 cases and 80,734 controls) and Zhou et al. [31] (18,945 cases 388,756 controls). This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.