The differential expression analysis showed that the IHC score of ULBP2 protein in COAD tumor tissues was significantly higher than in adjacent normal tissues (P < 0.0001), and the diagnostic ROC curve analysis suggested that the IHC score of ULBP2 protein has a certain diagnostic value in COAD [P = 0.003, AUC [95% CI =0.709 (0.584–0.834)] (Figure 5E, 5F). The gene discussed is ULBP2; the disease is neoplasm.