At the same time, the ULBP2 gene was involved in the COAD OS [adjusted P = 0.025, HR (95% CI) = 1.765 (1.074–2.901)], and the low regulation of ULBP2 had a favorable prognosis of COAD OS (Figure 2, Supplementary Table 3). The gene discussed is ULBP2; the disease is colon adenocarcinoma.