PALM2AKAP2 and Graves disease: Indeed, PALM2 and AKAP2, which can form fusion transcripts, constitute potential KS disease genes, since a female with KS and Graves’ disease carried a missense mutation, which was predicted to be deleterious, in PALM2 (16), and a male with KS and bone anomalies carried a balanced chromosomal translocation that disrupted AKAP2 expression (17).