ZNF462 and Global developmental delay: Haploinsufficiency of ZNF462 is associated with Weiss–Kruszka syndrome (3), the most typical symptoms of which include developmental delay, ptosis, metopic ridge, facial asymmetry, corpus callosum dysgenesis, down-slanting palpebral fissures, arched eyebrows, epicanthal folds, short upturned nose with a bulbous tip, marked cupid bow/wide philtrum, low set ears, hypertelorism, and hearing loss (3, 5).