SINE was developed to inhibit tumor growth by blocking the nuclear-cytoplasmic transport mechanism (i.e., exportins 1–7), where the majority of bulky cargo proteins above 40kD including TSP and GRP, and many RNAs were transported through, and thus leading to accumulation of TSP/GRP, and apoptosis of cancer cells [1]. This evidence concerns the gene XPO1 and neoplasm.