Moreover, loss of KDM4B inhibits the activity of STAT3 to suppress the progression of colorectal cancer (Chen et al. 2014; Deng et al. 2018), and KDM4B regulates the differentiation of vascular smooth muscle cells into osteoblast-like cells through interacting with STAT3 (Kurozumi et al. 2019). This evidence concerns the gene STAT3 and colorectal cancer.