Moreover, loss of KDM4B promotes DNA damage through inhibiting the activity of STAT3 signaling pathway in colorectal cancer (Chen et al. 2014; Deng et al. 2018), and stimulation with IL-6/sIL-6R suppresses H3K9me3 through the recruitment of KDM4B at the STAT-binding site in RUNX2 promoter region to induce differentiation of human vascular smooth muscle cells into osteoblast-like cells (Kurozumi et al. 2019). This evidence concerns the gene STAT3 and colorectal cancer.