However, when administered with IL-12, IL-7 markedly increased the clonality of CD8+ T cells, resulting in a higher proportion of mice treated with hIL-7/mIL-12-VV than mIL-12-VV showing multiple high-frequency clones in tumors, which seemed to correlate with the proportion of mice that achieved complete tumor regression. This evidence concerns the gene CD8A and neoplasm.