PROCR and malaria: In general, plasma samples from malaria-naive as well as severe cases showed lower mean fluorescence intensity (MFI) values for all antigens tested in comparison to samples from pre-exposed or non-severe cases with significant differences for CIDRα2–6, CIDRδ1, and CIDRγ3, but not for EPCR-binding CIDRα1 domains (Figure 7A,B).