This was consistent with the more frequent recognition of CIDRα1 domains than CIDRα2–6 domains in pre-exposed patients, indicating that IgG against EPCR-binding CIDR domains were acquired before IgG to other CIDR domains, as has been observed for malaria endemic populations (Obeng-Adjei et al., 2020; Cham et al., 2009; Cham et al., 2010; Turner et al., 2015). Here, PROCR is linked to malaria.