Moreover, some missense mutations in OTOF have been reported in patients showing a temperature-sensitive phenotype (Varga et al. 2006; Romanos et al. 2009; Marlin et al. 2010; Wang et al. 2010; Matsunaga et al. 2012; Zhang et al. 2016), while few have been associated with progressive hearing loss (Chiu et al. 2010; Yildirim-Baylan et al. 2014; Fedick et al. 2016). The gene discussed is OTOF; the disease is hearing loss disorder.