LDLR and Hypercholesterolemia: Subsequent studies with NEP25/LDLR−/− mice indicated that podocyte-specific injury in context with hypercholesterolemia leads to glomerular lipid peroxidation and formation of lysophosphatidylcholine (LPC) 16:0 and 18:0, affecting the expression of chemokines and adhesion molecules essential for macrophage attraction and migration.