Older age, male sex, obesity, hypertension, chronic pulmonary diseases, CVD, active cancer [3–6, 21], laboratory parameters (e.g. low lymphocyte count, and elevations in CRP, ALT and AST) [48] have been linked to a poor prognosis of COVID-19 in the general population infected with SARS-CoV-2. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.