Several genetic polymorphisms were studied for their association with CAD and myocardial infarction (MI) risk, such as factor v Leiden, factor II prothrombin, endothelial nitric oxide synthase (eNOS), methyltetrahydrofolate reductase (MTHFR), plasminogen activator inhibitor type 1 (PAI-1), paraoxonase (PON-1), APOA5 (apo-lipoprotein A5) [4-8]. The gene discussed is NOS3; the disease is coronary artery disorder.