ACE and hypertensive disorder: RAS genes polymorphisms play a major role in the pathogenesis and complications of essential hypertension, LVH, HCM, and cardiac remodeling; thus, highlighting the beneficial effect of angiotensin-converting enzyme inhibitors (ACEIs) such as enalapril and angiotensin receptor blockers (ARBs) such as losartan in these conditions as well as protecting the kidneys.