RAS genes polymorphisms play a major role in the pathogenesis and complications of essential hypertension, LVH, HCM, and cardiac remodeling; thus, highlighting the beneficial effect of angiotensin-converting enzyme inhibitors (ACEIs) such as enalapril and angiotensin receptor blockers (ARBs) such as losartan in these conditions as well as protecting the kidneys. Here, ACE is linked to essential hypertension.