MAP: mean arterial pressure; BMI: body mass index; LDL-C: low-densitylipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HbA1c:glycated hemoglobin; MetS: metabolic syndrome; CES-D: Center for EpidemiologicStudies Depression Scale; SRT: Selective Reminding Test; BVRT: Benton VisualRetention Test; WAIS-R: Wechsler Adult Intelligence Scale-Revised; BDAE: BostonDiagnostic Aphasia Evaluation; CFL: Controlled Oral Word Association; APOE:apolipoprotein E genotypes. This evidence concerns the gene APOE and major depressive disorder.