Our findings showed further differences in APOE alleles, underscoring anincreased number of test failures in the ε3-ε4 as compared to the ε3-ε3 group.Furthermore, the length of time patients have diabetes is associated with greatercognitive decline after 20 years; this association is dependent on HbA1c levels, andgreater cognitive decline observed with HbA1c >7%.9 This evidence concerns the gene APOE and Mental deterioration.