As there are some reports regarding the apoptotic effects of TGF-β signaling on LSCs, the CD34+ CML cells were pre-treated with BMP and TGF-β1 and stained with Annexin-V-FITC and Propidium Iodide (PI). This evidence concerns the gene TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive.