In COVID-19 patients, levels of IL-1β, IL-1RA, IL-7, IL-8, IL-9, IL-10, granulocyte colony stimulating factor (G-CSF), IFN-γ, interferon γ inducible protein (IP)-10, tumor necrosis factor-alpha (TNF-α) and MCP-1 are also increased over the healthy controls and become worsen in those admitted to ICU with severe acute lung injury 62, 63. This evidence concerns the gene CSF3 and acute lung injury.