Moreover, immune-suppressive functions of Bregs with IL-10 secretion in colitis (Mizoguchi et al., 2002), EAE (Fillatreau et al., 2002), arthritis (Mauri et al., 2003) and Helicobacter infection (Sayi et al., 2011) have been demonstrated. The gene discussed is IL10; the disease is arthritic joint disease.